Module leads: Dr. Peter Balfe and Prof. Tim Mitchell

Module code: 01 27583

Credits: 15

Attendance: Teaching delivered on Fridays for five consecutive weeks

Module dates: 22 February – 22 March 2019

Learning hours: 150 hours – teaching and private study

Three places are available for NHS staff on this module, thanks to funding from Health Education England.

The student will learn about the genomic structure of infectious agents, implication of acquisition or loss of nucleotides, genes and plasmids on pathogenicity, sensitivity of a pathogen to drug treatment and response to the host.

By the end of the module students should be able to:

  • Explain the differences between prokaryote and eukaryote genomes
  • Discuss and appraise how the genome sequence of pathogens can be used to track cross infection and outbreaks of infections among the population
  • Critically evaluate the emerging action of drugs in controlling infection e.g. HIV, TB
  • Critically evaluate the molecular basis of organism drug resistance in some infections and how this directs drug research
  • Evaluate how sequencing of the genome of infective organisms can be used in infectious disease for assessing: diagnosis, sub-classification and strain identity, pathogenicity, drug resistance and drug selection; and for epidemic control

Assessment: The module will be assessed via a short presentation, an exam made up of short answer questions and a choice of essay (exam typically around five-six weeks after the teaching).