Module lead: Professor Paul Murray
Module code: 01 27581
Attendance: Teaching delivered on Fridays for five consecutive weeks
Module dates: 09 Nov 2018, 16 Nov 2018, 23 Nov 2018, 07 Dec 2018, 14 Dec 2018
Learning hours: 150 hours – teaching and private study
Three places are still available on this course for NHS staff, thanks to Health Education England funding.
This module covers the molecular mechanisms that underlie cancer development, growth and metastasis, and the differences between different cancers. It will explore the different molecular and cellular actions of anti-cancer treatments, the genomic factors affecting response and resistance to treatment, and the research approaches to anti-cancer drug design and development. Broad situations which confer a high cancer risk to a person and/or to other members of the same family will be discussed in the context of how genomic information may be integrated into cancer screening programmes. This module will prepare the students to interrogate the cancer data sets from the 100,000 Genomes Project.
By the end of the module students should be able to:
- Apply the principles of cancer development and emerging changes in classification
- Compare and contrast the genomic basis of cancer predisposition, and how this is used to identify people and families at higher risk of cancer
- Critically evaluate how genomic information is currently applied in the diagnosis, classification, treatment selection and monitoring of cancer (e.g. leukaemia, breast, melanoma, lung cancers)
- Analyse how information from exome and whole genome analysis of tumour tissue can be used to investigate the molecular and cellular processes leading to cancer and inform strategies for drug development
Assessment: The module will be assessed via a poster presentation, a 3000-word essay assignment and short-answer/case study problems completed in your own time (essay submission date typically around five-six weeks after the teaching)